Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.59 |
| ▸ | FNTA | P49354 | 15/20 | 0.58 |
| ▸ | FNTB | P49356 | 15/20 | 0.58 |
| ▸ | PGGT1B | P53609 | 11/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | NRAS | P01111 | 1/20 | 0.48 |
| ▸ | HRAS | P01112 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097856 | 1.00 | KCNH2 (0.59) | KCNH2FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL8098295 | 0.93 | FNTA (0.49) | KCNH2FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL8442897 | 0.93 | FNTA (0.49) | KCNH2FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL8095394 | 0.92 | FNTA (0.60) | KCNH2FNTAFNTBPGGT1BCYP11B1 | |
| SCHEMBL8530784 | 0.92 | FNTA (0.51) | KCNH2FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL8088212 | 0.92 | FNTA (0.51) | KCNH2FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL8095370 | 0.90 | FNTA (0.49) | KCNH2FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL8095356 | 0.90 | CYP11B1 (0.51) | KCNH2FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL8428073 | 0.90 | CYP11B1 (0.51) | KCNH2FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL8443240 | 0.90 | FNTA (0.49) | KCNH2FNTAFNTBPGGT1BCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862435-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-02-03 | — | — | EP | claimed |
| EP-0862435-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-09-09 | — | — | EP | claimed |
| WO-1997018813-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-05-29 | — | — | WO | claimed |
| US-6127366-A | ANTICARCINOGENIC OR ANTITUMOR AGENTS | MERCK & CO., INC. (US) | 2000-10-03 | — | — | US | disclosed |
| EP-0862435-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-02-03 | — | — | EP | disclosed |
| US-5817678-A | IMIDAZOLE-CONTAINING PIPERIDINE DERIVATIVES, PEPTIDEMIMETIC | MERCK & CO., INC. (US) | 1998-10-06 | — | — | US | disclosed |
| EP-0862435-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-09-09 | — | — | EP | disclosed |
| WO-1997018813-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-05-29 | — | — | WO | disclosed |