Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.37 |
| ▸ | PPID | Q08752 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22591638 | 0.86 | GFER (0.50) | TDP1GFERALDH1A1CYP3A4TSHR | |
| SCHEMBL18524330 | 0.83 | TDP1 (0.39) | TDP1GFERALDH1A1CYP3A4TSHR | |
| SCHEMBL19934200 | 0.83 | TDP1 (0.42) | TDP1GFERALDH1A1CYP3A4TSHR | |
| SCHEMBL15159013 | 0.83 | SLC6A4 (0.45) | TDP1GFERALDH1A1CYP3A4TSHR | |
| SCHEMBL9455527 | 0.83 | IDO1 (0.45) | TSHRSLC6A2SLC6A3 | |
| SCHEMBL2406779 | 0.81 | TSHR (0.50) | TDP1GFERALDH1A1CYP3A4TSHR | |
| SCHEMBL9141621 | 0.80 | GFER (0.44) | TDP1GFERALDH1A1CYP3A4TSHR | |
| SCHEMBL8094863 | 0.80 | CYP3A4 (0.64) | TDP1GFERALDH1A1CYP3A4TSHR | |
| SCHEMBL17550075 | 0.80 | GFER (0.44) | TDP1GFERALDH1A1CYP3A4TSHR | |
| SCHEMBL9141614 | 0.80 | GFER (0.44) | TDP1GFERALDH1A1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009015203-A1 | NOVEL COMPOUNDS AND METHODS OF USING THEM | SYNDAX PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |
| WO-2009015237-A1 | NOVEL COMPOUNDS AND METHODS OF USING THEM | SYNDAX PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |