Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.41 |
| ▸ | MTOR | P42345 | 4/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8099345 | 0.87 | PIK3CD (0.44) | PIK3CDPIK3CAMTORPIK3CG | |
| SCHEMBL8083676 | 0.87 | PIK3CA (0.46) | PIK3CDPIK3CAMTORPIK3CG | |
| SCHEMBL8093006 | 0.87 | PIK3CD (0.42) | PIK3CDPIK3CAMTORPIK3CGF2 | |
| SCHEMBL8105807 | 0.86 | PIK3CD (0.42) | PIK3CDPIK3CA | |
| SCHEMBL8100085 | 0.86 | NAMPT (0.38) | PIK3CDPIK3CAF2F7 | |
| SCHEMBL8098293 | 0.86 | PIK3CA (0.42) | PIK3CDPIK3CAMTORPIK3CGATR | |
| SCHEMBL8083011 | 0.85 | ATR (0.39) | PIK3CDPIK3CAMTORATR | |
| SCHEMBL8083702 | 0.85 | PIK3CD (0.41) | PIK3CDPIK3CAMTORPIK3CG | |
| SCHEMBL8088889 | 0.85 | PIK3CD (0.44) | PIK3CDPIK3CAMTORPIK3CG | |
| SCHEMBL8092989 | 0.85 | PIK3CA (0.46) | PIK3CDPIK3CAMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |