SCHEMBL8090149

SCHEMBL8090149

COC12CCC(c3ccc(C(=O)NC(CCCB(O)O)NC(=N)N)cc3)(CC1)CC2

nearest known ligand 0.31

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SPHK1 Q9NYA1 3/20 0.31
HDAC3 O15379 1/20 0.31
HDAC4 P56524 1/20 0.31
HDAC1 Q13547 1/20 0.31
HDAC7 Q8WUI4 1/20 0.31
HDAC2 Q92769 1/20 0.31
HDAC10 Q969S8 1/20 0.31
HDAC11 Q96DB2 1/20 0.31
HDAC8 Q9BY41 1/20 0.31
HDAC6 Q9UBN7 1/20 0.31
HDAC9 Q9UKV0 1/20 0.31
HDAC5 Q9UQL6 1/20 0.31
CCR1 P32246 1/20 0.30
SPHK2 Q9NRA0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8098126 0.88 HDAC3 (0.31) HDAC3HDAC4HDAC1HDAC7HDAC2
Hydrochloric Acid SCHEMBL7449239 0.86 CCR1 (0.32) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL8095303 0.78 F2 (0.40) SPHK1CCR1
SCHEMBL8095297 0.78 F2 (0.40) SPHK1CCR1
SCHEMBL8083538 0.77 F2 (0.39)
SCHEMBL8083536 0.77 F2 (0.39)
SCHEMBL8090137 0.74 NPC1 (0.45) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL8090090 0.74 NPY4R (0.32) SPHK1
SCHEMBL8090092 0.73 NPY4R (0.31)
SCHEMBL8090105 0.72 F2 (0.37) CCR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0792883-B1 Novel derivates of boronic acid, process for their preparation and pharmaceutical compositions containing them ADIR (FR) 2000-12-20 EP claimed