Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 10/20 | 0.55 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.54 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.53 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.53 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.51 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.51 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090417 | 1.00 | KDM4E (0.56) | KDM4EABCB1ABCC9KCNE1KCNQ1 | |
| SCHEMBL8090416 | 1.00 | KDM4E (0.56) | KDM4EABCB1ABCC9KCNE1KCNQ1 | |
| SCHEMBL482281 | 0.88 | KDM4E (0.62) | KDM4EABCB1ABCC9KCNE1KCNQ1 | |
| SCHEMBL9185586 | 0.88 | KDM4E (0.62) | KDM4EABCB1ABCC9KCNE1KCNQ1 | |
| SCHEMBL9185591 | 0.88 | KDM4E (0.62) | KDM4EABCB1ABCC9KCNE1KCNQ1 | |
| SCHEMBL10642982 | 0.85 | KDM4E (0.60) | KDM4EABCB1ABCC9KCNE1KCNQ1 | |
| SCHEMBL8076989 | 0.85 | KDM4E (0.56) | KDM4EABCB1ABCC9KCNE1KCNQ1 | |
| SCHEMBL9194163 | 0.85 | KDM4E (0.60) | KDM4EABCB1ABCC9KCNE1KCNQ1 | |
| SCHEMBL10642972 | 0.85 | KDM4E (0.60) | KDM4EABCB1ABCC9KCNE1KCNQ1 | |
| SCHEMBL9210518 | 0.84 | KDM4E (0.55) | KDM4EABCB1ABCC9KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409651-B1 | New Process for the preparation of anti-hypertensive benzopyran derivative | ALKALOIDA VEGYESZETI GYAR (HU) | 1995-05-03 | — | — | EP | claimed |
| EP-0409651-A1 | New Process for the preparation of anti-hypertensive benzopyran derivative | ALKALOIDA VEGYESZETI GYAR (HU) | 1991-01-23 | — | — | EP | claimed |
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| EP-0385584-B1 | Method for the preparation of 4-(cyclic-amido)-2H-1-benzopyrans and 4-amino-3-hydroxy-2H-1-benzopyrans | BEECHAM GROUP PLC (GB) | 1995-05-24 | — | — | EP | disclosed |
| EP-0409651-B1 | New Process for the preparation of anti-hypertensive benzopyran derivative | ALKALOIDA VEGYESZETI GYAR (HU) | 1995-05-03 | — | — | EP | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0412760-B1 | Benzopyran derivatives | BEECHAM GROUP PLC (GB) | 1994-11-23 | — | — | EP | disclosed |
| US-5223629-A | Reacting 4-cyanophenol with isoprene, followed by bromination, dehydrobromination and reaction with 2-pyrrolidone, potassium channel activators | ALKALOIDA VEGYESZETI GYAR (HU) | 1993-06-29 | — | — | US | disclosed |
| EP-0277611-B1 | ALKYL-SUBSTITUTED N-BENZOPYRANYL LACTAMES, PROCESS FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS ON THE BASIS OF THESE COMPOUNDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-06-16 | — | — | EP | disclosed |
| US-5145985-A | From cyanophenol and isoprene and pyrrolidone, Kromakalim | ALKALOIDA VEGYESZETI GYAR (HU) | 1992-09-08 | — | — | US | disclosed |
| EP-0120427-A1 | 3,4-Dihydro-thiaoxo-1-pyrrolidinyl-or piperidinyl-ZH-benzo[b]pyrons | BEECHAM GROUP PLC (GB) | 1984-10-03 | — | — | EP | disclosed |
| US-4446113-A | HYPOTENSIVE AGENTS | BEECHAM GROUP P.L.C. (GB) | 1984-05-01 | — | — | US | disclosed |
| EP-0095316-A1 | Pharmaceutically active aminobenzopyrans | BEECHAM GROUP PLC (GB) | 1983-11-30 | — | — | EP | disclosed |
| EP-0093535-A1 | Novel chromenes and chromans | BEECHAM GROUP PLC (GB) | 1983-11-09 | — | — | EP | disclosed |
| US-4391815-A | VASODILATION, HYPOTENSIVE | BEECHAM GROUP LIMITED (GB) | 1983-07-05 | — | — | US | disclosed |
| EP-0009912-B1 | CHROMANOL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | BEECHAM GROUP PLC (GB) | 1983-06-22 | — | — | EP | disclosed |
| EP-0076075-A1 | Pharmaceutically active benzopyran compounds | BEECHAM GROUP PLC (GB) | 1983-04-06 | — | — | EP | disclosed |
| US-4251537-A | Hypotensive 3,4-dihydro-2,2-dimethyl-4-amino-2H-benzo[b]pyran-3-ols | BEECHAM GROUP LIMITED (GB) | 1981-02-17 | — | — | US | disclosed |
| EP-0009912-A1 | Chromanol derivatives, a process for their preparation and pharmaceutical compositions comprising them | BEECHAM GROUP PLC (GB) | 1980-04-16 | — | — | EP | disclosed |