Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Mannitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | ARG2 | P78540 | 4/20 | 0.42 |
| ▸ | ARG1 | P05089 | 3/20 | 0.42 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 5/20 | 0.38 |
| ▸ | NOS1 | P29475 | 3/20 | 0.38 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mannitol SCHEMBL1168590 | 0.95 | GSR (0.71) | GSRUSP2SLCO1B1PDE4AARG2 | |
| Mannitol SCHEMBL27538921 | 0.95 | GSR (0.71) | GSRUSP2SLCO1B1PDE4AARG2 | |
| Sorbitol SCHEMBL4751532 | 0.95 | GSR (0.71) | GSRUSP2SLCO1B1PDE4AARG2 | |
| Galactitol SCHEMBL1167727 | 0.95 | GSR (0.71) | GSRUSP2SLCO1B1PDE4AARG2 | |
| Mannitol SCHEMBL27929505 | 0.93 | GSR (0.69) | GSRUSP2SLCO1B1PDE4AARG2 | |
| Lysine SCHEMBL7614410 | 0.92 | GSR (0.71) | GSRUSP2SLCO1B1PDE4AARG2 | |
| Lysine SCHEMBL28944838 | 0.92 | GSR (0.77) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL11327123 | 0.92 | GSR (0.77) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL28033142 | 0.92 | GSR (0.77) | GSRARG2ARG1RNPEPNOS2 | |
| Gluconic Acid SCHEMBL16193997 | 0.89 | GSR (0.62) | GSRUSP2SLCO1B1PDE4AARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136554-A | RAPID AND COST EFFECTIVE METHOD BY INOCULATING NUTRIENT CULTURE CONTAINING CONCENTRATION OF PROPIONIC ACID AND/OR ITS SALTS WHICH INHIBIT OTHER BACTERIA AND CHROMOGENIC COMPOUNDS, INCUBATING, DETECTING COLORED COLONIES; ESCHERICHIA | BIOLOG, INC. (US) | 2000-10-24 | — | — | US | disclosed |
| WO-1996040861-A1 | MICROBIOLOGICAL MEDIA FOR ISOLATION AND IDENTIFICATION OF ENTERIC PATHOGENS SUCH AS E. COLI AND SALMONELLA | BIOLOG, INC. (US) | 1996-12-19 | — | — | WO | disclosed |