Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.67 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | PTGES | O14684 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | YAP1 | P46937 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ns-398 SCHEMBL9505682 | 0.81 | CYP19A1 (0.98) | CYP19A1PTGS2ALDH1A1PTGS1MEN1 | |
| Ns-398 SCHEMBL214213 | 0.80 | CYP19A1 (1.00) | CYP19A1PTGS2ALDH1A1PTGS1MEN1 | |
| SCHEMBL9504767 | 0.80 | CYP19A1 (1.00) | CYP19A1PTGS2ALDH1A1PTGS1MEN1 | |
| Ns-398 SCHEMBL29368077 | 0.80 | CYP19A1 (1.00) | CYP19A1PTGS2ALDH1A1PTGS1MEN1 | |
| Ns-398 SCHEMBL9505633 | 0.79 | CYP19A1 (0.98) | CYP19A1PTGS2ALDH1A1PTGS1MEN1 | |
| Ns-398 SCHEMBL9505672 | 0.79 | CYP19A1 (0.98) | CYP19A1PTGS2ALDH1A1PTGS1MEN1 | |
| Ns-398 SCHEMBL9505669 | 0.79 | CYP19A1 (0.98) | CYP19A1PTGS2ALDH1A1PTGS1MEN1 | |
| Ns-398 SCHEMBL9505627 | 0.79 | CYP19A1 (0.98) | CYP19A1PTGS2ALDH1A1PTGS1MEN1 | |
| SCHEMBL3296493 | 0.79 | CYP19A1 (1.00) | CYP19A1PTGS2ALDH1A1PTGS1MEN1 | |
| SCHEMBL8523784 | 0.78 | PTGS1 (0.61) | CYP19A1PTGS2ALDH1A1PTGS1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848703-B1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 2000-09-27 | — | — | EP | disclosed |
| US-6004948-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | NYCOMED AUSTRIA GMBH (AT) | 1999-12-21 | — | — | US | disclosed |
| EP-0848703-A1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | Nycomed Austria GmbH (AT) | 1998-06-24 | — | — | EP | disclosed |
| WO-1997003953-A1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 1997-02-06 | — | — | WO | disclosed |