Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22220534 | 0.75 | NPSR1 (0.36) | NPSR1MEN1KMT2ACYP3A4 | |
| SCHEMBL16647796 | 0.73 | TSHR (0.31) | TSHRNPSR1POLBCYP3A4 | |
| SCHEMBL13777970 | 0.72 | NPSR1 (0.38) | TSHRNPSR1MAPTMEN1KMT2A | |
| SCHEMBL31261785 | 0.72 | NPSR1 (0.38) | TSHRNPSR1MAPTMEN1KMT2A | |
| SCHEMBL16771682 | 0.72 | NPSR1 (0.38) | TSHRNPSR1MAPTMEN1KMT2A | |
| SCHEMBL1472063 | 0.71 | FFAR3 (0.37) | NPSR1POLBMAPTMEN1KMT2A | |
| SCHEMBL622852 | 0.71 | FFAR3 (0.37) | NPSR1POLBMAPTMEN1KMT2A | |
| SCHEMBL11660306 | 0.70 | NPSR1 (0.39) | TSHRNPSR1MAPTMEN1KMT2A | |
| SCHEMBL8089735 | 0.69 | CYP1A2 (0.35) | POLBMAPTMEN1KMT2ACYP3A4 | |
| SCHEMBL4870839 | 0.69 | NPSR1 (0.38) | TSHRNPSR1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009013535-A1 | 2-AZABICYCLO(2.2.2)OCTANE DERIVATIVES AS MODULATORS OF THE GLYCINE TRANSPORTER I RECEPTOR | ASTRAZENECA AB (SE) | 2009-01-29 | — | — | WO | disclosed |