Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Estradiol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 7/20 | 0.89 |
| ▸ | LMNA | P02545 | 7/20 | 0.89 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.89 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.89 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.89 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.89 |
| ▸ | MEN1 | O00255 | 3/20 | 0.89 |
| ▸ | TSHR | P16473 | 2/20 | 0.89 |
| ▸ | PGR | P06401 | 2/20 | 0.89 |
| ▸ | AR | P10275 | 2/20 | 0.89 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.89 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.89 |
| ▸ | RECQL | P46063 | 2/20 | 0.89 |
| ▸ | MAPT | P10636 | 2/20 | 0.89 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.89 |
| ▸ | SHBG | P04278 | 2/20 | 0.89 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.89 |
| ▸ | HTR2B | P41595 | 2/20 | 0.89 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.89 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Estradiol SCHEMBL3223253 | 1.00 | ESR1 (0.89) | ESR1LMNAHSD17B10ESR2KMT2A | |
| Estradiol SCHEMBL301392 | 1.00 | ESR1 (0.89) | ESR1LMNAHSD17B10ESR2KMT2A | |
| Estradiol SCHEMBL9273501 | 0.94 | ESR1 (0.87) | ESR1LMNAHSD17B10ESR2KMT2A | |
| Estradiol SCHEMBL5887626 | 0.94 | ESR1 (0.91) | ESR1LMNAHSD17B10ESR2KMT2A | |
| Estradiol SCHEMBL28211603 | 0.94 | ESR1 (0.95) | ESR1LMNAHSD17B10ESR2KMT2A | |
| Estradiol SCHEMBL24037697 | 0.94 | ESR1 (1.00) | ESR1LMNAHSD17B10ESR2KMT2A | |
| Estradiol SCHEMBL18258335 | 0.94 | ESR1 (1.00) | ESR1LMNAHSD17B10ESR2KMT2A | |
| Estradiol SCHEMBL15610005 | 0.94 | ESR1 (1.00) | ESR1LMNAHSD17B10ESR2KMT2A | |
| Estradiol SCHEMBL19235633 | 0.94 | ESR1 (1.00) | ESR1LMNAHSD17B10ESR2KMT2A | |
| Estradiol SCHEMBL7260525 | 0.94 | ESR1 (1.00) | ESR1LMNAHSD17B10ESR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054675-A1 | REGULATION OF ESTRUS AND OVULATION IN GILTS | Thorn Bioscience, LLC (US) | 2000-11-29 | — | — | EP | disclosed |
| US-6028057-A | INDUCING PSEUDOPREGNANCY IN FERTILE FEMALE PIGS COMPRISING ADMINISTERING TO THE PIGS AN EFFECTIVE AMOUNT OF A COMPOUND THAT INDUCES PSEUDOPREGNANCY IN A BIODEGRADABLE CONTROLLED RELEASE FORMULATION | THORN BIOSCIENCE, LLC (US) | 2000-02-22 | — | — | US | disclosed |
| US-6013276-A | TREATING MENOPAUSE OR OSTEOPOROSIS USING A TRANSDERMAL MATRIX SYSTEM CONTAINING ETHYLENE-VINYL ACETATE COPOLYMER, 2-OCTADODECYL MYRISTATE, N(C4-C15)ALKYL-2-PYRROLIDONES AND ATLEAST ONE HORMONE SELECTED FROM PROGESTIN AND ESTROGEN | LABORATORIES D'HYGIENE ET DE DIETETIQUE (FR) | 2000-01-11 | — | — | US | disclosed |
| WO-1999042110-A1 | REGULATION OF ESTRUS AND OVULATION IN GILTS | THORN BIOSCIENCE, LLC (US) | 1999-08-26 | — | — | WO | disclosed |
| US-5605702-A | Eva-based transdermal matrix system for the administration of an estrogen and/or a progestogen | LABORATOIRES D'HYGIENE ET DE DIETETIQUE (FR) | 1997-02-25 | — | — | US | disclosed |
| CN-1114587-A | EVA-based transdermal matrix system for the administration of an oestrogen and/or progestogen | LHD LAB HYGIENE DIETETIQUE (FR) | 1996-01-10 | — | — | CN | disclosed |
| US-4961931-A | Method for the management of hyperplasia | ALZA CORPORATION (US) | 1990-10-09 | — | — | US | disclosed |
| US-4842864-A | Self-adhesive device for the percutaneous administration of an active ingredient | LABORATORIES D'HYGIENE ET DE DIETETIQUE (FR) | 1989-06-27 | — | — | US | disclosed |
| US-4629449-A | Vaginal dispenser for dispensing beneficial hormone | ALZA CORPORATION (US) | 1986-12-16 | — | — | US | disclosed |
| US-4402695-A | Device for delivering agent in vagina | ALZA CORPORATION (US) | 1983-09-06 | — | — | US | disclosed |