Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | EDNRB | P24530 | 2/20 | 0.37 |
| ▸ | EDNRA | P25101 | 2/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28626535 | 0.76 | KCNN4 (0.49) | KCNN4ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL618735 | 0.73 | KMT2A (0.44) | KCNN4KMT2ALMNAKDM4ESMN1; SMN2 | |
| SCHEMBL28261002 | 0.67 | HPGD (0.49) | ALDH1A1AKR1C3AKR1C2ACACBKMT2A | |
| SCHEMBL10717798 | 0.67 | CYP1A2 (0.52) | KCNN4KIF11ALDH1A1EDNRBEDNRA | |
| SCHEMBL1470523 | 0.66 | CES1 (0.73) | KCNN4KIF11ALDH1A1EDNRBEDNRA | |
| SCHEMBL1626673 | 0.66 | PLK1 (0.47) | KCNN4KIF11ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL16713397 | 0.64 | CYP2D6 (0.49) | KCNN4KIF11KMT2ALMNAKDM4E | |
| SCHEMBL3931951 | 0.64 | KCNN4 (0.67) | KCNN4ALDH1A1MEN1KMT2AOPRM1 | |
| SCHEMBL27564046 | 0.64 | KCNN4 (0.60) | KCNN4KIF11MEN1KMT2AOPRM1 | |
| SCHEMBL18095170 | 0.63 | SRC (0.46) | KCNN4ALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882015-B1 | DIPHENYL STILBENES AS PRODRUGS TO COX-2 INHIBITORS | MERCK FROSST CANADA INC (CA) | 2000-12-27 | — | — | EP | disclosed |
| EP-0882015-A1 | DIPHENYL STILBENES AS PRODRUGS TO COX-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1998-12-09 | — | — | EP | disclosed |
| US-5733909-A | ANTIINFLAMMATORY AGENTS; ANALGESICS; ANTIPYRETIC AGENT | MERCK FROSST CANADA, INC. (CA) | 1998-03-31 | — | — | US | disclosed |
| WO-1997028120-A1 | DIPHENYL STILBENES AS PRODRUGS TO COX-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1997-08-07 | — | — | WO | disclosed |