Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 20/20 | 1.00 |
| ▸ | HTR1B | P28222 | 20/20 | 1.00 |
| ▸ | HTR1A | P08908 | 5/20 | 1.00 |
| ▸ | HTR2A | P28223 | 5/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR1E | P28566 | 1/20 | 0.50 |
| ▸ | HTR1F | P30939 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | HTR5A | P47898 | 1/20 | 0.50 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474847 | 0.90 | HTR1D (0.82) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7478803 | 0.81 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7478800 | 0.81 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2A | |
| Methylamine SCHEMBL8096304 | 0.80 | HTR1D (0.66) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7481032 | 0.79 | HTR1D (0.66) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL4578602 | 0.79 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL4358113 | 0.79 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL4578911 | 0.79 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL4358107 | 0.79 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL9047260 | 0.77 | HTR1D (0.66) | HTR1DHTR1BHTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025374-A | Azetidine, pyrrolidine and piperidine derivatives as 5HT1 receptor agonists | MERCK SHARP & DOHME, LTD. (GB) | 2000-02-15 | — | — | US | disclosed |