Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.61 |
| ▸ | JAK3 | P52333 | 4/20 | 0.61 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.60 |
| ▸ | IGF1R | P08069 | 1/20 | 0.58 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.53 |
| ▸ | CDK9 | P50750 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13588456 | 0.91 | JAK2 (0.67) | JAK2JAK3ZAP70IGF1RTNIK | |
| Hydrochloric Acid SCHEMBL4383810 | 0.90 | JAK2 (0.66) | JAK2JAK3ZAP70IGF1RTNIK | |
| SCHEMBL4376766 | 0.87 | JAK2 (0.72) | JAK2JAK3ZAP70IGF1RCCNT1 | |
| SCHEMBL4379791 | 0.86 | JAK2 (0.62) | JAK2JAK3ZAP70IGF1R | |
| SCHEMBL12801393 | 0.84 | JAK2 (0.69) | JAK2JAK3ZAP70IGF1RTNIK | |
| SCHEMBL1668203 | 0.84 | JAK2 (0.59) | JAK2JAK3ZAP70IGF1RTNIK | |
| SCHEMBL4383496 | 0.83 | JAK2 (0.59) | JAK2JAK3ZAP70IGF1RCCNT1 | |
| SCHEMBL4376839 | 0.83 | JAK2 (0.56) | JAK2JAK3ZAP70MTORPIK3CA | |
| SCHEMBL4376667 | 0.83 | JAK2 (0.74) | JAK2JAK3ZAP70IGF1RCCNT1 | |
| SCHEMBL4376656 | 0.83 | JAK2 (0.74) | JAK2JAK3ZAP70IGF1RCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |