Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | KDM6B | O15054 | 1/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10049724 | 0.87 | POLB (0.60) | MAPTSMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL8081936 | 0.80 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL4273717 | 0.78 | NPC1 (0.75) | MAPTSMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL12467265 | 0.73 | GAA (0.63) | MAPTSMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL27496860 | 0.73 | MEN1 (0.53) | MAPTSMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL6208785 | 0.73 | HIF1A (0.49) | MAPTSMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL25256062 | 0.73 | HIF1A (0.59) | MAPTSMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL29402710 | 0.73 | HIF1A (0.59) | MAPTSMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL23401877 | 0.72 | SMN1; SMN2 (0.47) | MAPTSMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL14132909 | 0.72 | SMN1; SMN2 (0.65) | MAPTSMN1; SMN2NPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121305-A | 5,5'-DIHYDROXY-4,4'-BIPYRAZOLE COMPOUNDS OF GIVEN FORMULA; FREE RADICAL SCAVENGER; USE TO TREAT CEREBRAL ISCHEMIA, HEART DISEASE, CARCINOMA, AGING, INFLAMMATION OR DIGESTIVE SYSTEM DISEASE, OR IN DETECTION OF AN ACTIVE OXYGEN OR FREE RADICALS | DAIICHI RADIOISOTOPE LABORATORIES, LTD. (JP) | 2000-09-19 | — | — | US | disclosed |