Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 5/20 | 0.48 |
| ▸ | PDCD1 | Q15116 | 11/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 11/20 | 0.44 |
| ▸ | ATR | Q13535 | 11/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 10/20 | 0.44 |
| ▸ | ATRIP | Q8WXE1 | 10/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3596530 | 0.92 | POLB (0.59) | PIK3CAPIK3CDPOLBMTORPDCD1 | |
| SCHEMBL4211899 | 0.91 | POLB (0.53) | PIK3CAPIK3CDPOLBMTORPDCD1 | |
| SCHEMBL3597871 | 0.90 | PIK3CA (0.50) | PIK3CAPIK3CDPOLBMTORPDCD1 | |
| SCHEMBL739607 | 0.90 | PIK3CA (0.52) | PIK3CAPIK3CDPOLBMTORPDCD1 | |
| SCHEMBL3595007 | 0.89 | ATR (0.50) | PIK3CAPIK3CDPOLBMTORPDCD1 | |
| SCHEMBL8092741 | 0.88 | PIK3CA (0.49) | PIK3CAPIK3CDMTORPDCD1CD274 | |
| SCHEMBL4198599 | 0.88 | POLB (0.48) | PIK3CAPIK3CDPOLBMTORPDCD1 | |
| SCHEMBL3590651 | 0.87 | PIK3CA (0.56) | PIK3CAPIK3CDPOLBMTORPDCD1 | |
| SCHEMBL4201332 | 0.86 | POLB (0.48) | PIK3CAPIK3CDPOLBMTORPDCD1 | |
| SCHEMBL4301766 | 0.85 | POLB (0.47) | PIK3CAPIK3CDPOLBMTORPDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |