Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.55 |
| ▸ | CSF1R | P07333 | 3/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.55 |
| ▸ | KIT | P10721 | 3/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.55 |
| ▸ | PLK4 | O00444 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
| ▸ | PAK4 | O96013 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.55 |
| ▸ | MET | P08581 | 2/20 | 0.55 |
| ▸ | FLT1 | P17948 | 2/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.55 |
| ▸ | TYK2 | P29597 | 2/20 | 0.55 |
| ▸ | AXL | P30530 | 2/20 | 0.55 |
| ▸ | FLT4 | P35916 | 2/20 | 0.55 |
| ▸ | BLK | P51451 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8216114 | 0.99 | KDR (0.56) | KDRFGFR1CSF1RPDGFRBKIT | |
| SCHEMBL8214293 | 0.91 | KDR (0.60) | KDRFGFR1CSF1RPDGFRBKIT | |
| SCHEMBL8093818 | 0.91 | KDR (0.60) | KDRFGFR1CSF1RPDGFRBKIT | |
| SCHEMBL8080265 | 0.90 | KDR (0.61) | KDRFGFR1CSF1RPDGFRBKIT | |
| SCHEMBL4056166 | 0.89 | KDR (0.62) | KDRFGFR1CSF1RPDGFRBKIT | |
| SCHEMBL4065256 | 0.89 | KDR (0.62) | KDRFGFR1CSF1RPDGFRBKIT | |
| SCHEMBL4060788 | 0.88 | KDR (0.63) | KDRFGFR1CSF1RPDGFRBKIT | |
| SCHEMBL8088651 | 0.87 | KDR (0.61) | KDRFGFR1CSF1RPDGFRBKIT | |
| SCHEMBL8087619 | 0.87 | KDR (0.59) | KDRFGFR1CSF1RPDGFRBKIT | |
| SCHEMBL4064374 | 0.87 | KDR (0.63) | KDRFGFR1CSF1RPDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009036066-A1 | VEGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |