Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.53 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.50 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5383294 | 0.85 | NR1H2 (0.54) | NR1H2SMARCA2SMARCA4PBRM1ALDH1A1 | |
| SCHEMBL993225 | 0.85 | MAPT (0.55) | NR1H2SMARCA2SMARCA4PBRM1ALDH1A1 | |
| SCHEMBL29508821 | 0.85 | MAPT (0.55) | NR1H2SMARCA2SMARCA4PBRM1ALDH1A1 | |
| SCHEMBL29569426 | 0.85 | NR1H2 (0.54) | NR1H2SMARCA2SMARCA4PBRM1ALDH1A1 | |
| SCHEMBL29508938 | 0.84 | NR1H2 (0.53) | NR1H2SMARCA2SMARCA4PBRM1ALDH1A1 | |
| SCHEMBL660403 | 0.84 | NR1H2 (0.53) | NR1H2SMARCA2SMARCA4PBRM1ALDH1A1 | |
| SCHEMBL447089 | 0.84 | NR1H2 (0.53) | NR1H2SMARCA2SMARCA4PBRM1ALDH1A1 | |
| SCHEMBL24992422 | 0.83 | NR1H2 (0.52) | NR1H2SMARCA2SMARCA4PBRM1ALDH1A1 | |
| SCHEMBL6807385 | 0.83 | NR1H2 (0.52) | NR1H2SMARCA2SMARCA4PBRM1ALDH1A1 | |
| SCHEMBL30890229 | 0.83 | NR1H2 (0.52) | NR1H2SMARCA2SMARCA4PBRM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009010454-A2 | AMIDO DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2009-01-22 | — | — | WO | disclosed |