Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.60 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | CLK2 | P49760 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757334 | 0.91 | TOP2A (0.56) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL9757274 | 0.91 | TOP2A (0.57) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL9757349 | 0.90 | TOP2A (0.56) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL9757511 | 0.89 | TOP2A (0.56) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL9757498 | 0.89 | TOP2A (0.56) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL9757420 | 0.89 | TOP2A (0.56) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL8093551 | 0.89 | TOP2A (0.53) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL9317503 | 0.89 | TOP2A (0.57) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL9757337 | 0.89 | TOP2A (0.53) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL9757256 | 0.89 | TOP2A (0.53) | TOP2ATOP2BALDH1A1POLBOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3181478-A | — | — | None | — | — | JP | disclosed |
| JP-2062875-A | — | — | None | — | — | JP | disclosed |
| US-6018054-A | INTERMEDIATE COMPOUNDS FOR PREPARING NOVEL QUINOLONE AND NAPHTHYRIDONE DERIVATIVES WHICH ARE SUBSTITUTED IN THE 7-POSITION BY A PARTIALLY HYDROGENATED ISOINDOLINYL RING, USE AS ANTIBACTERIAL AGENTS AND AS FEED ADDITIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-01-25 | — | — | US | disclosed |
| US-5739339-A | BACTERICIDES, ANTIPROTOZOA AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-04-14 | — | — | US | disclosed |
| US-5556979-A | ANIMAL FEEDS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-09-17 | — | — | US | disclosed |
| EP-0588166-B1 | Antibacterial 7-isoindolinyl-quinolone and naphthyridone derivatives | BAYER AG (DE) | 1996-06-05 | — | — | EP | disclosed |
| US-5464796-A | Bactericides and feed additives | BAYER AKTIENGESELLSCHAFT (DE) | 1995-11-07 | — | — | US | disclosed |
| US-5371090-A | Bactericides, feed additives | BAYER AKTIENGESELLSCHAFT (DE) | 1994-12-06 | — | — | US | disclosed |
| US-5312823-A | Antibacterials | BAYER AKTIENGESELLSCHAFT (DE) | 1994-05-17 | — | — | US | disclosed |
| EP-0588166-A2 | Antibacterial 7-isoindolinyl-quinolone and naphthyridone derivatives | BAYER AG (DE) | 1994-03-23 | — | — | EP | disclosed |
| EP-0520277-A2 | 7-Azaisoindolinyl-quinolone- and naphthyridoncarboxylic acid derivatives | BAYER AG (DE) | 1992-12-30 | — | — | EP | disclosed |
| EP-0520240-A1 | 7-Isoindolinyl-quinolone and naphthyridonecarboxylic acid derivatives | BAYER AG (DE) | 1992-12-30 | — | — | EP | disclosed |
| JP-H03181478-A | PYRIDINECARBOXYLIC ACID DERIVATIVE | BANYU PHARMACEUT CO LTD | 1991-08-07 | — | — | JP | disclosed |
| JP-H0262875-A | NOVEL ISOINDOLINE DERIVATIVE | WAKUNAGA PHARMACEUT CO LTD | 1990-03-02 | — | — | JP | disclosed |