Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 9/20 | 0.51 |
| ▸ | FNTA | P49354 | 10/20 | 0.50 |
| ▸ | FNTB | P49356 | 10/20 | 0.50 |
| ▸ | PGGT1B | P53609 | 10/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | ERG | P11308 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088612 | 1.00 | GPBAR1 (0.51) | GPBAR1FNTAFNTBPGGT1BCYP11B1 | |
| SCHEMBL8440130 | 0.89 | FNTA (0.58) | GPBAR1FNTAFNTBPGGT1BCYP11B1 | |
| SCHEMBL8097937 | 0.89 | FNTA (0.58) | GPBAR1FNTAFNTBPGGT1BCYP11B1 | |
| Hydrochloric Acid SCHEMBL7973982 | 0.88 | FNTA (0.57) | GPBAR1FNTAFNTBPGGT1BCYP11B1 | |
| SCHEMBL8088444 | 0.85 | FNTA (0.58) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL8095394 | 0.85 | FNTA (0.60) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL8437320 | 0.85 | GPBAR1 (0.52) | GPBAR1FNTAFNTBPGGT1BCYP11B1 | |
| SCHEMBL8098513 | 0.85 | GPBAR1 (0.52) | GPBAR1FNTAFNTBPGGT1BCYP11B1 | |
| SCHEMBL8088609 | 0.83 | FNTA (0.61) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL8095374 | 0.83 | FNTA (0.61) | FNTAFNTBPGGT1BCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862435-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-02-03 | — | — | EP | claimed |
| EP-0862435-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-09-09 | — | — | EP | claimed |
| WO-1997018813-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-05-29 | — | — | WO | claimed |
| US-6127366-A | ANTICARCINOGENIC OR ANTITUMOR AGENTS | MERCK & CO., INC. (US) | 2000-10-03 | — | — | US | disclosed |
| US-5817678-A | IMIDAZOLE-CONTAINING PIPERIDINE DERIVATIVES, PEPTIDEMIMETIC | MERCK & CO., INC. (US) | 1998-10-06 | — | — | US | disclosed |