Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phentermine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.70 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | GHSR | Q92847 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phentermine SCHEMBL8142147 | 0.86 | SLC6A2 (0.79) | SLC6A2TAAR1SMN1; SMN2HIF1AGHSR | |
| Phentermine SCHEMBL29261099 | 0.84 | SLC6A2 (0.91) | SLC6A2TAAR1SMN1; SMN2HIF1AGHSR | |
| Phentermine SCHEMBL10392295 | 0.84 | SLC6A2 (1.00) | SLC6A2TAAR1SMN1; SMN2HIF1AGHSR | |
| Phentermine SCHEMBL26615 | 0.84 | SLC6A2 (1.00) | SLC6A2TAAR1SMN1; SMN2HIF1AGHSR | |
| Phentermine SCHEMBL5930925 | 0.83 | SLC6A2 (0.73) | SLC6A2TAAR1SMN1; SMN2HIF1AGHSR | |
| Phentermine SCHEMBL6100624 | 0.83 | TAAR1 (0.73) | SLC6A2TAAR1SMN1; SMN2HIF1AGHSR | |
| Phentermine SCHEMBL6100627 | 0.83 | TAAR1 (0.73) | SLC6A2TAAR1SMN1; SMN2HIF1AGHSR | |
| Phentermine SCHEMBL28815884 | 0.83 | SLC6A2 (0.73) | SLC6A2TAAR1SMN1; SMN2HIF1AGHSR | |
| Phentermine SCHEMBL41585 | 0.82 | SLC6A2 (0.95) | SLC6A2TAAR1SMN1; SMN2HIF1AGHSR | |
| Phentermine SCHEMBL28729624 | 0.82 | SLC6A2 (0.95) | SLC6A2TAAR1SMN1; SMN2HIF1AGHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130347-A | REACTING MONOCHLOROACETIC ESTER WITH HYDROGEN CYANIDE IN BASE PRESENCE; CYANATION | BASF AKTIENGESELLSCHAFT (DE) | 2000-10-10 | — | — | US | disclosed |