Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.31 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.30 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL81548 | 0.83 | EGFR (0.52) | EGFRPIK3CDPIK3CATDO2FGFR4 | |
| SCHEMBL17511867 | 0.80 | EGFR (0.44) | EGFRPIK3CDPIK3CATDO2IMPDH2 | |
| SCHEMBL17511903 | 0.80 | EGFR (0.44) | EGFRPIK3CDPIK3CATDO2IMPDH2 | |
| SCHEMBL8010883 | 0.77 | PIK3CA (0.46) | EGFRPIK3CDPIK3CATDO2FGFR4 | |
| SCHEMBL17511933 | 0.73 | EGFR (0.33) | EGFR | |
| Quinazoline SCHEMBL27607879 | 0.71 | EGFR (0.95) | EGFRPIK3CDPIK3CATDO2IMPDH2 | |
| Quinazoline SCHEMBL27716390 | 0.71 | EGFR (0.95) | EGFRPIK3CDPIK3CATDO2IMPDH2 | |
| Quinazoline SCHEMBL28002188 | 0.71 | EGFR (0.95) | EGFRPIK3CDPIK3CATDO2IMPDH2 | |
| Quinazoline SCHEMBL27464750 | 0.71 | EGFR (0.95) | EGFRPIK3CDPIK3CATDO2IMPDH2 | |
| Quinazoline SCHEMBL8130188 | 0.71 | EGFR (0.95) | EGFRPIK3CDPIK3CATDO2IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2395 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024145659-A1 | HETEROCYCLE FUSED GAMMA-CARBOLINES ACTING ON THE SEROTONINE 5-HT2A RECEPTOR | INTRA-CELLULAR THERAPIES, INC. (US) | 2024-07-04 | — | — | WO | claimed |
| US-11952376-B2 | Substituted amino acids as integrin inhibitors | PLIANT THERAPEUTICS, INC. (US) | 2024-04-09 | — | — | US | claimed |
| CN-113166119-B | Substituted aryl compound and preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2024-01-05 | — | — | CN | claimed |
| WO-2023107630-A2 | AMINO ALCOHOL COMPOUNDS AND USES THEREOF | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | claimed |
| CN-114957110-A | Antiviral compound and preparation method and application thereof | 清华大学 | 2022-08-30 | — | — | CN | claimed |
| CN-114269731-A | KIF18A inhibitors | 美国安进公司 | 2022-04-01 | — | — | CN | claimed |
| EP-3904352-A1 | SUBSTITUTED ARYL COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2021-11-03 | — | — | EP | claimed |
| CN-113166119-A | Substituted aryl compound and preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2021-07-23 | — | — | CN | claimed |
| EP-3154941-B1 | SMALL MOLECULE LFA-1 INHIBITORS | ALLOCYTE PHARMACEUTICALS AG (CH) | 2021-01-20 | — | — | EP | claimed |
| WO-2020135210-A1 | SUBSTITUTED ARYL COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2020-07-02 | — | — | WO | claimed |
| WO-1998039303-A1 | SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1998-09-11 | — | — | WO | claimed |
| WO-1998023617-A1 | HETERO-BIARYL-PYRIDOQUINAZOLINONE DERIVATIVES AS ANTI-CANCER AGENTS | AMERICAN CYANAMID COMPANY (US) | 1998-06-04 | — | — | WO | claimed |
| EP-0822187-A1 | PYRAZOLE DERIVATIVES AND HERBICIDES | NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) | 1998-02-04 | — | — | EP | claimed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | claimed |
| CN-1144526-A | Thiazolidines and oxazolidines substituted by pyridine ring and their use a hypoglycemic agents | NISSAN CHEMICAL IND LTD (JP) | 1997-03-05 | — | — | CN | claimed |
| EP-0751944-A1 | THIAZOLIDINES AND OXAZOLIDINES SUBSTITUTED BY A PYRIDINE RING AND THEIR USE AS HYPOGLYCEMIC AGENTS | NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) | 1997-01-08 | — | — | EP | claimed |
| CN-1030196-C | Positive inotropic and lusitropic 3,5-dihydro-imidazo [2,1-6] quinazolin-2(1H)-one derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-11-01 | — | — | CN | claimed |
| WO-1995026347-A1 | THIAZOLIDINES AND OXAZOLIDINES SUBSTITUTED BY A PYRIDINE RING AND THEIR USE AS HYPOGLYCEMIC AGENTS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1995-10-05 | — | — | WO | claimed |
| EP-0289430-B1 | SWEETENERS DERIVED FROM GUANIDINOACETIC AND ETHANAMIDINOACETIC ACIDS, THEIR USES AND COMPOSITIONS CONTAINING THESE SWEETENERS | UNIVERSITE CLAUDE BERNARD - LYON 1 (FR) | 1992-04-08 | — | — | EP | claimed |
| CN-1051560-A | Contractile and relaxing force enhancing 3, 5-dihydroimidazo [2, 1-b ] quinazolin-2 (1H) -one derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1991-05-22 | — | — | CN | claimed |