Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | KHK | P50053 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | HTR1B | P28222 | 2/20 | 0.38 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573887 | 0.88 | KHK (0.46) | ACACBKHKMAPTTLR9TLR8 | |
| SCHEMBL4573515 | 0.86 | KHK (0.45) | KHKMAPTTLR9TLR8TLR7 | |
| SCHEMBL2245477 | 0.85 | TLR9 (0.47) | ACACBKHKMAPTTLR9TLR8 | |
| SCHEMBL5270098 | 0.85 | TLR9 (0.47) | ACACBKHKMAPTTLR9TLR8 | |
| SCHEMBL8112635 | 0.85 | TLR9 (0.48) | KHKMAPTTLR9TLR8TLR7 | |
| SCHEMBL8099603 | 0.85 | KHK (0.47) | KHKMAPTTLR9TLR8TLR7 | |
| SCHEMBL2248995 | 0.82 | TLR9 (0.43) | ACACBKHKMAPTTLR9TLR8 | |
| SCHEMBL2252323 | 0.82 | CHRM2 (0.42) | KHKMAPTTLR9TLR8TLR7 | |
| SCHEMBL5274632 | 0.82 | CHRM2 (0.42) | KHKMAPTTLR9TLR8TLR7 | |
| SCHEMBL13428956 | 0.82 | BCL2A1 (0.47) | KHKMAPTBCL2A1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |