Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.55 |
| ▸ | MTOR | P42345 | 6/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090036 | 0.89 | PIK3CA (0.59) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL4201695 | 0.88 | PIK3CA (0.58) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL761613 | 0.86 | PIK3CA (0.74) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL8215015 | 0.85 | PIK3CA (0.75) | PIK3CAPIK3CDMTOR | |
| SCHEMBL4201757 | 0.85 | PIK3CA (0.60) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL11926803 | 0.84 | PIK3CA (0.62) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL8218848 | 0.83 | PIK3CA (0.61) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL8214611 | 0.83 | PIK3CA (0.60) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL4207128 | 0.82 | PIK3CA (0.57) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL8098040 | 0.82 | PIK3CA (0.59) | PIK3CAPIK3CDMTORPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007750-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |
| WO-2009007749-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |