Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 16/20 | 1.00 |
| ▸ | HTR2B | P41595 | 15/20 | 1.00 |
| ▸ | HTR2A | P28223 | 12/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097675 | 1.00 | HTR2C (1.00) | HTR2CHTR2BHTR2ASLC6A4SLC6A3 | |
| SCHEMBL15255094 | 1.00 | HTR2C (1.00) | HTR2CHTR2BHTR2ASLC6A4SLC6A3 | |
| SCHEMBL8332679 | 0.88 | HTR2C (0.78) | HTR2CHTR2BHTR2ASLC6A4SLC6A3 | |
| SCHEMBL20205056 | 0.85 | HTR2C (0.74) | HTR2CHTR2BHTR2ACHRM2CHRM1 | |
| SCHEMBL22334915 | 0.85 | HTR2C (0.74) | HTR2CHTR2BHTR2ACHRM2CHRM1 | |
| SCHEMBL23995531 | 0.85 | HTR2C (0.74) | HTR2CHTR2BHTR2ACHRM2CHRM1 | |
| SCHEMBL8332428 | 0.84 | HTR2C (0.72) | HTR2CHTR2BHTR2ACHRM2CHRM1 | |
| SCHEMBL8088821 | 0.84 | HTR2C (0.72) | HTR2CHTR2BHTR2ACHRM2CHRM1 | |
| SCHEMBL8088819 | 0.84 | HTR2C (0.72) | HTR2CHTR2BHTR2ACHRM2CHRM1 | |
| SCHEMBL1841186 | 0.83 | HTR2C (0.71) | HTR2CHTR2BHTR2ASLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | disclosed |
| US-5889031-A | CONTROLLING CIRCADIAN RHYTHMS | BRISTOL-MYERS SQUIBB COMPNAY (US) | 1999-03-30 | — | — | US | disclosed |
| US-5753709-A | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-19 | — | — | US | disclosed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |