Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 9/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | IDH2 | P48735 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21644922 | 0.92 | FFAR1 (0.45) | FFAR1HTR2AHTR2CHTR2BPTGDR2 | |
| SCHEMBL20103281 | 0.91 | PTGDR2 (0.52) | FFAR1HTR2AHTR2CHTR2BPTGDR2 | |
| SCHEMBL21644868 | 0.87 | FFAR1 (0.51) | FFAR1PTGDR2SLC6A4 | |
| SCHEMBL21644953 | 0.87 | FFAR1 (0.45) | FFAR1PTGDR2DPP4 | |
| SCHEMBL20103540 | 0.87 | FFAR1 (0.51) | FFAR1PTGDR2SLC6A4 | |
| SCHEMBL24645999 | 0.87 | FFAR1 (0.47) | FFAR1HTR2APTGDR2SLC6A4 | |
| SCHEMBL20103513 | 0.87 | FFAR1 (0.51) | FFAR1PTGDR2SLC6A4 | |
| SCHEMBL20103493 | 0.87 | FFAR1 (0.45) | FFAR1PTGDR2DPP4 | |
| SCHEMBL20103517 | 0.87 | FFAR1 (0.51) | FFAR1PTGDR2SLC6A4 | |
| SCHEMBL20103359 | 0.87 | FFAR1 (0.45) | FFAR1PTGDR2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105492429-A | Heteroaryl inhibitors of SUMO activating enzyme | MILLENNIUM PHARM INC | 2016-04-13 | — | — | CN | disclosed |
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | disclosed |
| US-5889031-A | CONTROLLING CIRCADIAN RHYTHMS | BRISTOL-MYERS SQUIBB COMPNAY (US) | 1999-03-30 | — | — | US | disclosed |
| US-5753709-A | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-19 | — | — | US | disclosed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |