Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23630333 | 0.85 | MCOLN3 (0.50) | MCOLN3L3MBTL1POLBKMT2AALDH1A1 | |
| SCHEMBL3390197 | 0.83 | POLB (0.51) | MCOLN3L3MBTL1POLBKMT2AALDH1A1 | |
| SCHEMBL2389473 | 0.80 | MCOLN3 (0.50) | MCOLN3L3MBTL1POLBKMT2AMEN1 | |
| SCHEMBL9211270 | 0.80 | MCOLN3 (0.50) | MCOLN3L3MBTL1POLBKMT2AMEN1 | |
| SCHEMBL9865528 | 0.80 | MCOLN3 (0.50) | MCOLN3L3MBTL1POLBKMT2AMEN1 | |
| SCHEMBL2389980 | 0.80 | MCOLN3 (0.50) | MCOLN3L3MBTL1POLBKMT2AMEN1 | |
| SCHEMBL9380136 | 0.80 | MCOLN3 (0.50) | MCOLN3L3MBTL1POLBKMT2AMEN1 | |
| SCHEMBL9684628 | 0.80 | MCOLN3 (0.50) | MCOLN3L3MBTL1POLBKMT2AMEN1 | |
| SCHEMBL9685672 | 0.80 | MCOLN3 (0.50) | MCOLN3L3MBTL1POLBKMT2AMEN1 | |
| SCHEMBL27687424 | 0.77 | POLB (0.41) | MCOLN3L3MBTL1POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147800-A1 | PYRAZOLOPYRROLIDINES AS INHIBITORS OF GAMMA SECRETASE | ELAN PHARMACEUTICALS, INC. (US) | 2008-12-04 | — | — | WO | disclosed |