Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 19/20 | 0.76 |
| ▸ | EGFR | P00533 | 18/20 | 0.76 |
| ▸ | SRC | P12931 | 18/20 | 0.76 |
| ▸ | ABL2 | P42684 | 17/20 | 0.76 |
| ▸ | LCK | P06239 | 8/20 | 0.72 |
| ▸ | JAK2 | O60674 | 3/20 | 0.65 |
| ▸ | INSR | P06213 | 3/20 | 0.65 |
| ▸ | RET | P07949 | 3/20 | 0.65 |
| ▸ | IGF1R | P08069 | 3/20 | 0.65 |
| ▸ | KIT | P10721 | 3/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.65 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.65 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.65 |
| ▸ | KDR | P35968 | 3/20 | 0.65 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.65 |
| ▸ | NPM1 | P06748 | 2/20 | 0.65 |
| ▸ | CSF1R | P07333 | 2/20 | 0.65 |
| ▸ | LYN | P07948 | 2/20 | 0.65 |
| ▸ | MET | P08581 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8108060 | 0.95 | ABL1 (0.80) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL8107232 | 0.90 | ABL1 (0.78) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL7023786 | 0.89 | ABL1 (0.89) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL8108098 | 0.89 | SRC (0.62) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL8098878 | 0.89 | SRC (0.63) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL7021411 | 0.86 | ABL1 (1.00) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL7015822 | 0.86 | ABL1 (0.77) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL7021099 | 0.85 | ABL1 (0.75) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL7019164 | 0.84 | ABL1 (1.00) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL8107295 | 0.84 | EGFR (0.86) | ABL1EGFRSRCABL2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051577-A | TYROSINE INHIBITORS; BONE DISORDERS | NOVARTIS AG (CH) | 2000-04-18 | — | — | US | disclosed |