Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 14/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | IKBKB | O14920 | 1/20 | 0.59 |
| ▸ | QPCT | Q16769 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chs-828 SCHEMBL810184 | 1.00 | NAMPT (1.00) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL809874 | 1.00 | NAMPT (1.00) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL810340 | 1.00 | NAMPT (1.00) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL809897 | 1.00 | NAMPT (1.00) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL810114 | 1.00 | NAMPT (1.00) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| Chs-828 SCHEMBL23924547 | 1.00 | NAMPT (1.00) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| Chs-828 SCHEMBL2672576 | 1.00 | NAMPT (1.00) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| Chs-828 SCHEMBL7148795 | 0.99 | NAMPT (0.98) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| Chs-828 SCHEMBL7142973 | 0.99 | NAMPT (0.98) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8916372 | 0.90 | NAMPT (0.82) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394649-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING PYRIDYL CYANOGUANIDINES, PREPARATION METHODS AND USES THEREOF | Tianjin Hemay Bio-Tech Co., Ltd. (CN) | 2011-12-14 | — | — | EP | claimed |
| EP-2394649-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING PYRIDYL CYANOGUANIDINES, PREPARATION METHODS AND USES THEREOF | Tianjin Hemay Bio-Tech Co., Ltd. (CN) | 2011-12-14 | — | — | EP | disclosed |