Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 5/20 | 0.57 |
| ▸ | SRD5A2 | P31213 | 5/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.45 |
| ▸ | HSD17B7 | P56937 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7897448 | 1.00 | SRD5A1 (0.57) | SRD5A1SRD5A2CYP19A1HSD17B7 | |
| SCHEMBL8680324 | 0.86 | SRD5A1 (0.53) | SRD5A1SRD5A2 | |
| SCHEMBL8725586 | 0.85 | SRD5A1 (0.52) | SRD5A1SRD5A2 | |
| SCHEMBL8725589 | 0.85 | SRD5A1 (0.52) | SRD5A1SRD5A2 | |
| SCHEMBL8725591 | 0.85 | SRD5A1 (0.52) | SRD5A1SRD5A2 | |
| SCHEMBL8938166 | 0.84 | SRD5A1 (0.56) | SRD5A1SRD5A2HSD17B7 | |
| SCHEMBL8938169 | 0.84 | SRD5A1 (0.56) | SRD5A1SRD5A2HSD17B7 | |
| SCHEMBL8093887 | 0.83 | SRD5A1 (0.53) | SRD5A1SRD5A2 | |
| SCHEMBL8093889 | 0.83 | SRD5A1 (0.53) | SRD5A1SRD5A2 | |
| SCHEMBL8570744 | 0.83 | SRD5A1 (0.53) | SRD5A1SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0778284-A2 | New 7-beta-substituted-4-aza-5alpha-androstan-3-ones as 5alpha-reductase inhibitors | MERCK & CO. INC. (US) | 1997-06-11 | — | — | EP | claimed |
| EP-0572166-A1 | New 7beta-substituted-4-aza-5a-androstan-3-ones as 5a-reductase inhibitors | MERCK & CO. INC. (US) | 1993-12-01 | — | — | EP | claimed |
| EP-0756481-B1 | 17$g(b)-ARYL-4-AZA-STEROID DERIVATIVES | MERCK & CO INC (US) | 2000-12-27 | — | — | EP | disclosed |
| EP-0756481-A4 | 17-g(b)-ARYL-4-AZA-STEROID DERIVATIVES | MERCK & CO INC (US) | 1998-11-18 | — | — | EP | disclosed |
| US-5710275-A | ENZYME AND HORMONE INHIBITORS | MERCK & CO., INC. (US) | 1998-01-20 | — | — | US | disclosed |
| EP-0778284-A2 | New 7-beta-substituted-4-aza-5alpha-androstan-3-ones as 5alpha-reductase inhibitors | MERCK & CO. INC. (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0756481-A1 | 17$g(b)-ARYL-4-AZA-STEROID DERIVATIVES | MERCK & CO. INC. (US) | 1997-02-05 | — | — | EP | disclosed |
| US-5525608-A | ANTIACNE AGENT, SKIN DISORDERS, GLANDULAR DISORDERS | MERCK & CO., INC. (US) | 1996-06-11 | — | — | US | disclosed |
| WO-1995028928-A1 | 17β-ARYL-4-AZA-STEROID DERIVATIVES | MERCK & CO., INC. (US) | 1995-11-02 | — | — | WO | disclosed |
| US-5359071-A | Selective antagonist of testosterone 5-alpha-reductase 1 | MERCK & CO., INC. (US) | 1994-10-25 | — | — | US | disclosed |
| EP-0572166-A1 | New 7beta-substituted-4-aza-5a-androstan-3-ones as 5a-reductase inhibitors | MERCK & CO. INC. (US) | 1993-12-01 | — | — | EP | disclosed |