Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1926306 | 0.88 | USP2 (0.46) | USP2SMN1; SMN2RECQLCA12CA1 | |
| SCHEMBL12021701 | 0.85 | USP2 (0.53) | USP2SMN1; SMN2RECQLHSD17B10CA12 | |
| SCHEMBL12021512 | 0.85 | USP2 (0.53) | USP2SMN1; SMN2RECQLHSD17B10CA12 | |
| SCHEMBL315706 | 0.85 | USP2 (0.53) | USP2SMN1; SMN2RECQLHSD17B10CA12 | |
| SCHEMBL925405 | 0.82 | USP2 (0.53) | USP2SMN1; SMN2RECQLHSD17B10ATM | |
| SCHEMBL16604806 | 0.81 | SMN1; SMN2 (0.49) | USP2SMN1; SMN2RECQLHSD17B10CA12 | |
| SCHEMBL16604796 | 0.81 | SMN1; SMN2 (0.49) | USP2SMN1; SMN2RECQLHSD17B10CA12 | |
| SCHEMBL3511572 | 0.81 | SMN1; SMN2 (0.49) | USP2SMN1; SMN2RECQLHSD17B10CA12 | |
| SCHEMBL18684984 | 0.81 | USP2 (0.49) | USP2SMN1; SMN2RECQLHSD17B10ATM | |
| SCHEMBL315705 | 0.81 | USP2 (0.51) | USP2SMN1; SMN2RECQLHSD17B10CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |