Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 2/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | GHSR | Q92847 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | DPP4 | P27487 | 3/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2243476 | 0.88 | TLR9 (0.55) | KHKTLR9TLR8TLR7CHEK1 | |
| SCHEMBL8270689 | 0.88 | TLR9 (0.55) | KHKTLR9TLR8TLR7CHEK1 | |
| Hydrochloric Acid SCHEMBL4572995 | 0.87 | TLR9 (0.54) | KHKTLR9TLR8TLR7CHEK1 | |
| SCHEMBL2867159 | 0.84 | BCL2A1 (0.50) | KHKTLR9TLR8TLR7CHEK1 | |
| SCHEMBL13066645 | 0.84 | TLR9 (0.47) | KHKTLR9TLR8TLR7CHEK1 | |
| SCHEMBL1639654 | 0.84 | BCL2A1 (0.50) | KHKTLR9TLR8TLR7CHEK1 | |
| SCHEMBL2873748 | 0.84 | CHEK1 (0.47) | KHKTLR9TLR8TLR7CHEK1 | |
| SCHEMBL1639658 | 0.84 | BCL2A1 (0.50) | KHKTLR9TLR8TLR7CHEK1 | |
| SCHEMBL2873745 | 0.84 | CHEK1 (0.47) | KHKTLR9TLR8TLR7CHEK1 | |
| SCHEMBL8110949 | 0.84 | TLR9 (0.45) | KHKTLR9TLR8TLR7CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |