Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 20/20 | 0.52 |
| ▸ | ATRIP | Q8WXE1 | 4/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.49 |
| ▸ | TAF1 | P21675 | 3/20 | 0.47 |
| ▸ | MTOR | P42345 | 2/20 | 0.47 |
| ▸ | PRKDC | P78527 | 2/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097048 | 0.90 | MTOR (0.51) | ATRATRIPPIK3CATAF1MTOR | |
| SCHEMBL4202269 | 0.88 | ATR (0.54) | ATRATRIPPIK3CATAF1MTOR | |
| SCHEMBL8089432 | 0.88 | ATR (0.53) | ATRATRIPPIK3CATAF1MTOR | |
| SCHEMBL4198807 | 0.88 | ATR (0.54) | ATRATRIPPIK3CATAF1MTOR | |
| SCHEMBL4201331 | 0.84 | ATR (0.53) | ATRATRIPPIK3CATAF1MTOR | |
| SCHEMBL4201670 | 0.83 | ATR (0.51) | ATRATRIPPIK3CATAF1MTOR | |
| SCHEMBL4207731 | 0.82 | ATR (0.54) | ATRATRIPPIK3CATAF1MTOR | |
| SCHEMBL4204399 | 0.82 | ATR (0.52) | ATRATRIPPIK3CATAF1MTOR | |
| SCHEMBL4204062 | 0.82 | MTOR (0.49) | ATRATRIPPIK3CATAF1MTOR | |
| SCHEMBL4198804 | 0.82 | ATR (0.52) | ATRATRIPPIK3CATAF1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |