Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 15/20 | 0.57 |
| ▸ | MTOR | P42345 | 5/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3926730 | 0.88 | ATR (0.60) | ATRMTORPIK3CAPIK3CDPIK3CB | |
| SCHEMBL3929781 | 0.87 | MTOR (0.56) | ATRMTORPIK3CAPIK3CDPIK3CB | |
| SCHEMBL8099689 | 0.87 | ATR (0.52) | ATRMTORPIK3CAPIK3CDPIK3CB | |
| SCHEMBL3930394 | 0.86 | PIK3CA (0.65) | ATRMTORPIK3CAPIK3CDPIK3CB | |
| SCHEMBL3935141 | 0.85 | PIK3CA (0.50) | ATRMTORPIK3CAPIK3CDPIK3CB | |
| SCHEMBL3926393 | 0.85 | KMT2A (0.58) | ATRMTORPIK3CAPIK3CDPIK3CB | |
| SCHEMBL4198492 | 0.84 | ATR (0.55) | ATRMTORPIK3CAPIK3CDPIK3CB | |
| SCHEMBL8089670 | 0.81 | PIK3CA (0.62) | ATRMTORPIK3CAPIK3CDPIK3CB | |
| SCHEMBL3933003 | 0.79 | ATR (0.49) | ATRMTORPIK3CA | |
| SCHEMBL3930064 | 0.79 | MTOR (0.55) | ATRMTORPIK3CAPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |