Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RARB | P10826 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2741668 | 0.87 | ESR1 (0.64) | ESR1ESR2MCHR1LTA4HMAPK1 | |
| SCHEMBL8176484 | 0.86 | MAPT (0.51) | ESR1ESR2MCHR1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL224473 | 0.85 | ESR1 (0.62) | ESR1ESR2MCHR1LTA4HMAPK1 | |
| SCHEMBL8134642 | 0.84 | KDM4E (0.69) | ESR1KDM4EALDH1A1THRA | |
| SCHEMBL465181 | 0.82 | KDM4E (0.65) | KDM4ETHRARARB | |
| SCHEMBL30726463 | 0.82 | KDM4E (0.65) | KDM4ETHRARARB | |
| SCHEMBL465148 | 0.82 | KDM4E (0.65) | KDM4ETHRAMAPK1RARB | |
| SCHEMBL8092814 | 0.82 | BCHE (0.56) | ESR1KDM4EALDH1A1THRA | |
| SCHEMBL8189320 | 0.80 | MCHR1 (0.49) | ESR1ESR2MCHR1THRA | |
| SCHEMBL8084842 | 0.80 | KDM4E (0.62) | KDM4ETHRARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810206-B1 | Substituted 2-naphthoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicament containing them | HOECHST AG (DE) | 2000-12-27 | — | — | EP | disclosed |
| US-6087304-A | ANTIARRHYTHMIC PHARMACEUTICALS HAVING A CARDIOPROTECTIVE COMPONENT FOR INFARCT PROPHYLAXIS AND INFARCT TREATMENT AND FOR THE TREATMENT OF ANGINA PECTORIS | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-07-11 | — | — | US | disclosed |
| EP-0810206-A1 | Substituted 2-naphtoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-12-03 | — | — | EP | disclosed |