Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 6/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12035985 | 0.80 | MAPT (0.41) | MAPTALDH1A1KDM4EHIF1AEPAS1 | |
| SCHEMBL12036000 | 0.78 | MAPT (0.40) | MAPTALDH1A1KDM4EHIF1AEPAS1 | |
| SCHEMBL10573500 | 0.78 | HTR2A (0.40) | MAPTALDH1A1KDM4EHIF1AEPAS1 | |
| SCHEMBL5269029 | 0.78 | MAPT (0.40) | MAPTALDH1A1KDM4EHIF1AEPAS1 | |
| SCHEMBL15724661 | 0.78 | AKR1B1 (0.46) | MAPTALDH1A1KDM4EHIF1AEPAS1 | |
| SCHEMBL3047236 | 0.78 | AKT1 (0.44) | MAPTALDH1A1KDM4EHIF1AEPAS1 | |
| SCHEMBL5546007 | 0.78 | MAPT (0.60) | MAPTALDH1A1KDM4EGAAPTPN1 | |
| SCHEMBL5546004 | 0.78 | MAPT (0.44) | MAPTALDH1A1KDM4EHIF1AEPAS1 | |
| SCHEMBL7957662 | 0.77 | MAPT (0.67) | MAPTALDH1A1KDM4EGLAGAA | |
| SCHEMBL12035990 | 0.76 | HPGD (0.40) | MAPTALDH1A1KDM4EHIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008139941-A1 | SUBSTITUTED IMIDAZOLE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-11-20 | — | — | WO | disclosed |