SCHEMBL8104671

SCHEMBL8104671

CN(C)CCc1cc2cc([N+](=O)[O-])ccc2[nH]1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.48
HRH4 Q9H3N8 1/20 0.43
MAPT P10636 4/20 0.42
POLB P06746 3/20 0.42
MAOB P27338 1/20 0.42
NOS1 P29475 1/20 0.42
KDM4E B2RXH2 1/20 0.42
GRIA1 P42261 1/20 0.42
GRIA2 P42262 1/20 0.42
GRIA3 P42263 1/20 0.42
GRIA4 P48058 1/20 0.42
HTT P42858 1/20 0.41
RXFP1 Q9HBX9 1/20 0.41
ALDH1A1 P00352 4/20 0.41
LMNA P02545 2/20 0.41
KCNJ1 P48048 1/20 0.41
CHRNB2 P17787 1/20 0.41
CHRNA4 P43681 1/20 0.41
CA12 O43570 1/20 0.38
CA9 Q16790 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7807147 0.84 KDM4E (0.55) CYP19A1HRH4MAPTPOLBMAOB
SCHEMBL9486575 0.82 CYP19A1 (0.49) CYP19A1HRH4MAPTPOLBMAOB
SCHEMBL6597520 0.81 CYP19A1 (0.51) CYP19A1HRH4MAPTPOLBMAOB
SCHEMBL6257538 0.81 CYP19A1 (0.54) CYP19A1HRH4MAPTPOLBMAOB
SCHEMBL3962933 0.81 CYP19A1 (0.48) CYP19A1HRH4MAPTPOLBMAOB
SCHEMBL28923795 0.81 KCNH2 (0.50) CYP19A1HRH4MAPTPOLBMAOB
SCHEMBL6257958 0.81 CYP19A1 (0.48) CYP19A1HRH4MAPTPOLBMAOB
SCHEMBL27532988 0.79 CYP19A1 (0.55) CYP19A1HRH4MAPTPOLBMAOB
SCHEMBL27602612 0.79 CYP19A1 (0.52) CYP19A1HRH4MAPTPOLBMAOB
SCHEMBL8802605 0.79 CYP19A1 (0.49) CYP19A1HRH4MAPTPOLBMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1036058-A1 ADAMANTANE DERIVATIVES AstraZeneca UK Limited (GB) 2000-09-20 EP disclosed
WO-1999029660-A1 ADAMANTANE DERIVATIVES ASTRAZENECA UK LIMITED (GB) 1999-06-17 WO disclosed