Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 1/20 | 0.61 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.61 |
| ▸ | PTGDR2 | Q9Y5Y4 | 10/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.52 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2087562 | 0.89 | PTGDR2 (0.75) | AKR1B10AKR1B1PTGDR2CYP2C9HDAC6 | |
| SCHEMBL2246361 | 0.88 | PTGDR2 (0.66) | PTGDR2CYP2C9HDAC6HDAC1KDM4E | |
| SCHEMBL23148492 | 0.88 | PTGDR2 (0.59) | AKR1B10AKR1B1PTGDR2CYP2C9HDAC6 | |
| SCHEMBL2248432 | 0.87 | HDAC6 (0.66) | AKR1B10AKR1B1PTGDR2CYP2C9HDAC6 | |
| SCHEMBL29224005 | 0.86 | PTGDR2 (0.64) | AKR1B10AKR1B1PTGDR2CYP2C9KDM4E | |
| SCHEMBL14067841 | 0.85 | HDAC1 (0.61) | AKR1B10AKR1B1PTGDR2CYP2C9HDAC6 | |
| SCHEMBL8039548 | 0.83 | HDAC6 (0.69) | AKR1B10AKR1B1PTGDR2HDAC6HDAC1 | |
| SCHEMBL12868112 | 0.83 | KDM4E (0.57) | AKR1B10AKR1B1PTGDR2CYP2C9KDM4E | |
| SCHEMBL14067778 | 0.81 | KDM4E (0.61) | PTGDR2HDAC6HDAC1KDM4ELMNA | |
| SCHEMBL8041005 | 0.80 | HDAC6 (0.60) | AKR1B10AKR1B1PTGDR2HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0716661-B1 | PSEUDO- AND NON-PEPTIDE BRADYKININ RECEPTOR ANTAGONISTS | SCIOS INC (US) | 2000-04-05 | — | — | EP | disclosed |
| US-5817756-A | USING A MODIFIED DI- OR TRI-PEPTIDES | SCIOS INC. (US) | 1998-10-06 | — | — | US | disclosed |
| EP-0716661-A1 | PSEUDO- AND NON-PEPTIDE BRADYKININ RECEPTOR ANTAGONISTS | SCIOS NOVA INC. (US) | 1996-06-19 | — | — | EP | disclosed |
| WO-1995007294-A1 | PSEUDO- AND NON-PEPTIDE BRADYKININ RECEPTOR ANTAGONISTS | SCIOS NOVA INC. (US) | 1995-03-16 | — | — | WO | disclosed |