Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.57 |
| ▸ | AKT1 | P31749 | 3/20 | 0.57 |
| ▸ | MTOR | P42345 | 4/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL729588 | 0.84 | PIK3CA (0.64) | PIK3CAAKT1MTORPIK3CDPIK3CB | |
| SCHEMBL8119215 | 0.78 | PIK3CA (0.57) | PIK3CAAKT1MTORPIK3CDPIK3CB | |
| SCHEMBL14024679 | 0.78 | PIK3CA (0.57) | PIK3CAAKT1MTORPIK3CDPIK3CB | |
| SCHEMBL729945 | 0.78 | PIK3CA (0.66) | PIK3CAAKT1MTORPIK3CDPIK3CB | |
| SCHEMBL731497 | 0.77 | PIK3CA (0.65) | PIK3CAAKT1MTORPIK3CDPIK3CB | |
| SCHEMBL8132469 | 0.77 | PIK3CA (0.53) | PIK3CAAKT1MTORPIK3CDPIK3CB | |
| SCHEMBL729752 | 0.76 | PIK3CA (0.62) | PIK3CAAKT1MTORPIK3CDPIK3CB | |
| SCHEMBL8121050 | 0.76 | PIK3CA (0.55) | PIK3CAAKT1MTORPIK3CDPIK3CB | |
| SCHEMBL731678 | 0.76 | PIK3CA (0.75) | PIK3CAAKT1MTORPIK3CDPIK3CB | |
| SCHEMBL741238 | 0.75 | PIK3CA (0.74) | PIK3CAAKT1MTORPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144463-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | WO | disclosed |