Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.64 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.64 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.64 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.64 |
| ▸ | HRH2 | P25021 | 2/20 | 0.64 |
| ▸ | HTR2A | P28223 | 2/20 | 0.64 |
| ▸ | HTR2C | P28335 | 2/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.64 |
| ▸ | HRH1 | P35367 | 2/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.64 |
| ▸ | DRD3 | P35462 | 2/20 | 0.64 |
| ▸ | HTR2B | P41595 | 2/20 | 0.64 |
| ▸ | HTR6 | P50406 | 2/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12270467 | 0.89 | CYP2D6 (0.53) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL14134795 | 0.89 | CYP2D6 (0.53) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL4667597 | 0.87 | CYP2D6 (0.76) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL3992907 | 0.82 | SCN1A (0.55) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL25375446 | 0.81 | CYP2D6 (0.68) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL4669319 | 0.81 | CYP2D6 (0.68) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL5268174 | 0.80 | ESR1 (0.75) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL27533307 | 0.80 | IDO1 (0.49) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL1956043 | 0.80 | TSHR (0.48) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL9292047 | 0.80 | CYP2D6 (0.57) | CYP2D6CHRM2CHRM4CHRM5ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0983222-A1 | PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS | NYMOX CORPORATION (CA) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998052898-A1 | PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS | NYMOX CORPORATION (CA) | 1998-11-26 | — | — | WO | disclosed |