Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 10/20 | 0.49 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | USP1 | O94782 | 2/20 | 0.38 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8107148 | 0.90 | BRS3 (0.49) | BRS3ARUSP1WDR48TRPA1 | |
| Hydrochloric Acid SCHEMBL8661074 | 0.89 | BRS3 (0.49) | BRS3ARUSP1WDR48TRPA1 | |
| SCHEMBL7919370 | 0.88 | BRS3 (0.58) | BRS3ARUSP1WDR48 | |
| Hydrochloric Acid SCHEMBL8310488 | 0.86 | BRS3 (0.57) | BRS3ARUSP1WDR48 | |
| SCHEMBL7927535 | 0.85 | BRS3 (0.52) | BRS3CYP11B1CYP11B2 | |
| SCHEMBL8105183 | 0.84 | BRS3 (0.67) | BRS3 | |
| SCHEMBL8105181 | 0.82 | BRS3 (0.60) | BRS3USP1WDR48 | |
| SCHEMBL8107106 | 0.79 | BRS3 (0.51) | BRS3USP1WDR48CYP11B1CYP11B2 | |
| SCHEMBL7927590 | 0.78 | BRS3 (0.61) | BRS3 | |
| SCHEMBL8110764 | 0.78 | BRS3 (0.58) | BRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986302-A1 | A METHOD OF TREATING CANCER | Merck & Co., Inc. (US) | 2000-03-22 | — | — | EP | claimed |
| EP-0891333-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1998054966-A1 | A METHOD OF TREATING CANCER | MERCK & CO., INC. (US) | 1998-12-10 | — | — | WO | claimed |
| WO-1997036875-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | claimed |
| EP-0891333-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036875-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |