SCHEMBL8107790

SCHEMBL8107790

Cc1cccc(CN)c1.NCc1cccc(C(F)(F)F)c1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 2/20 0.59
HTR2A P28223 2/20 0.56
HTR2B P41595 2/20 0.56
HTR2C P28335 1/20 0.56
MAOB P27338 4/20 0.55
IDO1 P14902 3/20 0.53
MAPT P10636 2/20 0.50
CETP P11597 1/20 0.49
NFE2L2 Q16236 1/20 0.46
ACP3 P15309 1/20 0.46
SIGMAR1 Q99720 1/20 0.45
LMNA P02545 1/20 0.45
ADRA2C P18825 1/20 0.45
SLC6A4 P31645 1/20 0.45
ADRA1A P35348 1/20 0.45
DRD3 P35462 1/20 0.45
OPRK1 P41145 1/20 0.45
MIF P14174 1/20 0.45
EPHX1 P07099 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29463258 0.89 TAAR1 (0.71) TAAR1HTR2AHTR2BHTR2CMAOB
SCHEMBL39655 0.89 TAAR1 (0.71) TAAR1HTR2AHTR2BHTR2CMAOB
Ethylamine SCHEMBL4238530 0.87 TAAR1 (0.65) TAAR1HTR2AHTR2BHTR2CMAOB
Bromide SCHEMBL31513704 0.87 TAAR1 (0.69) TAAR1HTR2AHTR2BHTR2CMAOB
Hydrochloric Acid SCHEMBL11220775 0.87 TAAR1 (0.69) TAAR1HTR2AHTR2BHTR2CMAOB
Hydrochloric Acid SCHEMBL26616857 0.87 TAAR1 (0.69) TAAR1HTR2AHTR2BHTR2CMAOB
Bromide SCHEMBL11233006 0.87 TAAR1 (0.69) TAAR1HTR2AHTR2BHTR2CMAOB
Iodide SCHEMBL11221836 0.87 TAAR1 (0.69) TAAR1HTR2AHTR2BHTR2CMAOB
SCHEMBL18164547 0.86 TAAR1 (0.62) TAAR1HTR2AHTR2BHTR2CIDO1
SCHEMBL39821 0.83

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0973936-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 2000-01-26 EP disclosed
WO-1999031506-A9 PARALLEL SOLUTION PHASE SYNTHESIS OF LACTAMS LILLY CO ELI (US) 1999-09-16 WO disclosed
WO-1999031507-A1 PEPTIDOMIMETIC TEMPLATE-BASED COMBINATORIAL LIBRARIES ELI LILLY AND COMPANY (US) 1999-06-24 WO disclosed
WO-1999031506-A1 PARALLEL SOLUTION PHASE SYNTHESIS OF LACTAMS ELI LILLY AND COMPANY (US) 1999-06-24 WO disclosed
WO-1998046786-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 1998-10-22 WO disclosed