Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.62 |
| ▸ | AKT1 | P31749 | 3/20 | 0.62 |
| ▸ | MTOR | P42345 | 3/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 6/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.37 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.37 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.37 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.37 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.37 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL729989 | 0.88 | PIK3CA (0.68) | PIK3CAAKT1MTORPIK3C3PIK3CD | |
| SCHEMBL730319 | 0.86 | PIK3CA (0.72) | PIK3CAAKT1MTORPIK3C3PIK3CD | |
| SCHEMBL729558 | 0.86 | PIK3CA (0.71) | PIK3CAAKT1MTORPIK3C3PIK3CD | |
| SCHEMBL732174 | 0.83 | PIK3CA (0.72) | PIK3CAAKT1MTORPIK3C3PIK3CD | |
| SCHEMBL731322 | 0.82 | PIK3CA (0.66) | PIK3CAAKT1MTORPIK3C3PIK3CD | |
| SCHEMBL731305 | 0.82 | PIK3CA (0.61) | PIK3CAAKT1MTORPIK3C3PIK3CD | |
| SCHEMBL729900 | 0.82 | PIK3CA (0.71) | PIK3CAAKT1MTORPIK3C3PIK3CD | |
| SCHEMBL729947 | 0.81 | PIK3CA (0.64) | PIK3CAAKT1MTORPIK3C3PIK3CD | |
| SCHEMBL729822 | 0.80 | PIK3CA (0.77) | PIK3CAAKT1MTORPIK3C3PIK3CD | |
| SCHEMBL729300 | 0.80 | PIK3CA (0.67) | PIK3CAAKT1MTORPIK3C3PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144463-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | WO | disclosed |