Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 15/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.80 |
| ▸ | QPCT | Q16769 | 3/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8054100 | 1.00 | NAMPT (0.80) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL810132 | 1.00 | NAMPT (0.80) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL809885 | 1.00 | NAMPT (0.80) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8051027 | 1.00 | NAMPT (0.80) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8054321 | 1.00 | NAMPT (0.80) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL810154 | 1.00 | NAMPT (0.80) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL811171 | 1.00 | NAMPT (0.80) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL810473 | 1.00 | NAMPT (0.80) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6950783 | 0.99 | NAMPT (0.78) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8915411 | 0.95 | NAMPT (0.72) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394649-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING PYRIDYL CYANOGUANIDINES, PREPARATION METHODS AND USES THEREOF | Tianjin Hemay Bio-Tech Co., Ltd. (CN) | 2011-12-14 | — | — | EP | claimed |
| US-6121297-A | SUCH AS N-CYANO-N'-(11-PHENOXYUNDECYL)-N?-4-PYRIDYLGUANIDINE; N-CYANO-N'-(10-PHENOXYDECYL)-N?-4-PYRIDYLGUANIDINE; N-CYANO-N'-(9-PHENOXYNONYL)-N?-4-PYRIDYLGUANIDINE; OR THEIR SALTS; TREATING SKIN CANCER | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2000-09-19 | — | — | US | claimed |
| EP-2394649-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING PYRIDYL CYANOGUANIDINES, PREPARATION METHODS AND USES THEREOF | Tianjin Hemay Bio-Tech Co., Ltd. (CN) | 2011-12-14 | — | — | EP | disclosed |
| US-6121297-A | SUCH AS N-CYANO-N'-(11-PHENOXYUNDECYL)-N?-4-PYRIDYLGUANIDINE; N-CYANO-N'-(10-PHENOXYDECYL)-N?-4-PYRIDYLGUANIDINE; N-CYANO-N'-(9-PHENOXYNONYL)-N?-4-PYRIDYLGUANIDINE; OR THEIR SALTS; TREATING SKIN CANCER | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2000-09-19 | — | — | US | disclosed |