Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 3/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.44 |
| ▸ | PTPN22 | Q9Y2R2 | 2/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | KIFC1 | Q9BW19 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA4 | P22748 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7659206 | 0.84 | PLG (0.49) | PLGPRSS1PRSS2PRSS3PTPN1 | |
| SCHEMBL4315647 | 0.76 | KLKB1 (0.56) | PLGPRSS1PRSS2PRSS3PTPN1 | |
| SCHEMBL4315645 | 0.76 | KLKB1 (0.56) | PLGPRSS1PRSS2PRSS3PTPN1 | |
| SCHEMBL6571743 | 0.76 | KLKB1 (0.56) | PLGPRSS1PRSS2PRSS3PTPN1 | |
| SCHEMBL6575495 | 0.74 | PTPN1 (0.50) | PLGPRSS1PRSS2PRSS3PTPN1 | |
| SCHEMBL6575522 | 0.74 | PLG (0.50) | PLGPRSS1PRSS2PRSS3PTPN1 | |
| SCHEMBL8115466 | 0.73 | KLKB1 (0.51) | PLGPRSS1PRSS2PRSS3PTPN1 | |
| SCHEMBL6571390 | 0.72 | KLKB1 (0.51) | PLGPRSS1PRSS2PRSS3PTPN1 | |
| SCHEMBL6571395 | 0.72 | KLKB1 (0.51) | PLGPRSS1PRSS2PRSS3PTPN1 | |
| SCHEMBL6575213 | 0.72 | PTPN1 (0.54) | PTPN1PTPN22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019364-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999011606-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | PHARMACIA & UPJOHN COMPANY (US) | 1999-03-11 | — | — | WO | disclosed |