SCHEMBL8111485

SCHEMBL8111485

CCc1ccc(C(=O)Nc2cc(-c3ccccc3)ccc2O)cc1

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 20/20 0.77
HDAC2 Q92769 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3641983 0.87 HDAC1 (1.00) HDAC1HDAC2
SCHEMBL5724398 0.86 HDAC1 (1.00) HDAC1HDAC2
SCHEMBL3639290 0.86 HDAC1 (1.00) HDAC1HDAC2
SCHEMBL3638201 0.85 HDAC1 (1.00) HDAC1HDAC2
SCHEMBL3642943 0.85 HDAC1 (0.76) HDAC1HDAC2
SCHEMBL3643650 0.85 HDAC1 (1.00) HDAC1
SCHEMBL3643430 0.84 HDAC1 (1.00) HDAC1HDAC2
SCHEMBL3644493 0.82 HDAC1 (0.74) HDAC1HDAC2
SCHEMBL11699043 0.82 NPC1 (0.64) HDAC1HDAC2
SCHEMBL3644778 0.81 HDAC1 (1.00) HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009002495-A1 4-CARBOXYBENZYLAMINO DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS MERCK & CO., INC. (US) 2008-12-31 WO disclosed