Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 17/20 | 0.58 |
| ▸ | HTR1B | P28222 | 17/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | TACR2 | P21452 | 2/20 | 0.44 |
| ▸ | GLP1R | P43220 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480626 | 0.96 | HTR1D (0.59) | HTR1DHTR1BHTR1AADRA2CHTR2A | |
| SCHEMBL7482425 | 0.82 | HTR1D (0.68) | HTR1DHTR1BHTR1AADRA2CHTR2A | |
| SCHEMBL7477067 | 0.78 | HTR1D (0.77) | HTR1DHTR1B | |
| Oxalic Acid SCHEMBL8111216 | 0.78 | HTR1D (0.66) | HTR1DHTR1BHTR2AHTR2C | |
| Oxalic Acid SCHEMBL8111341 | 0.76 | HTR1D (0.73) | HTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL7477976 | 0.76 | HTR1D (0.69) | HTR1DHTR1BHTR1AADRA2CHTR2A | |
| SCHEMBL8413856 | 0.75 | HTR1D (0.66) | HTR1DHTR1BHTR1AADRA2CHTR2A | |
| Oxalic Acid SCHEMBL8110300 | 0.74 | HTR1D (0.73) | HTR1DHTR1B | |
| Oxalic Acid SCHEMBL8116236 | 0.74 | HTR1D (0.66) | HTR1DHTR1BHTR1AADRA2CHTR2A | |
| SCHEMBL8414642 | 0.74 | HTR1D (0.67) | HTR1DHTR1BHTR1AADRA2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048878-A | Substituted piperidine derivatives as selective agonists of 5-HT receptors | MERCK SHARP & DOHME LTD. (GB) | 2000-04-11 | — | — | US | disclosed |