SCHEMBL8113237

SCHEMBL8113237

COC(=O)CCc1ccc(OCC2CN(c3ccccc3)C(=O)O2)cc1

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 18/20 0.70
TP53 P04637 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2823101 0.90 GRM2 (0.70) GRM2
SCHEMBL9096938 0.90 GRM2 (0.64) GRM2
SCHEMBL2827370 0.90 GRM2 (0.72) GRM2
SCHEMBL7068100 0.87 GRM2 (0.52) GRM2
SCHEMBL7065822 0.86 GRM2 (0.52) GRM2
SCHEMBL2825762 0.85 GRM2 (0.83) GRM2
SCHEMBL8114429 0.83 GRM2 (0.72) GRM2
SCHEMBL2825508 0.82 GRM2 (1.00) GRM2
SCHEMBL2827884 0.82 GRM2 (1.00) GRM2
SCHEMBL8114140 0.81 GRM2 (0.66) GRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0605729-B1 OXAZOLIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF TAIHO PHARMACEUTICAL CO LTD (JP) 2000-07-26 EP disclosed
US-5480899-A ANTILIPEMIC AGENTS TAIHO PHARMACEUTICAL CO., LTD. (JP) 1996-01-02 US disclosed
EP-0605729-A1 OXAZOLIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF TAIHO PHARMACEUTICAL CO., LTD. (JP) 1994-07-13 EP disclosed