Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
| ▸ | LAP3 | P28838 | 2/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.30 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.30 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8113439 | 1.00 | TDP1 (0.41) | TDP1TSHRRNPEPSLC7A5CYP3A4 | |
| SCHEMBL6942402 | 0.85 | TDP1 (0.40) | TDP1TSHRCYP3A4TAS1R3TAS1R1 | |
| SCHEMBL6942403 | 0.85 | TDP1 (0.40) | TDP1TSHRCYP3A4TAS1R3TAS1R1 | |
| SCHEMBL15443387 | 0.82 | TDP1 (0.45) | TDP1TSHRCYP3A4TAS1R3TAS1R1 | |
| SCHEMBL6804648 | 0.82 | TDP1 (0.40) | TDP1TSHRRNPEPSLC7A5CYP3A4 | |
| SCHEMBL6368830 | 0.79 | TDP1 (0.41) | TDP1TSHRCYP3A4MAPTCACNA1B | |
| SCHEMBL7611792 | 0.77 | TDP1 (0.46) | TDP1TSHRRNPEPSLC7A5CYP3A4 | |
| SCHEMBL167950 | 0.76 | TSHR (0.43) | TDP1TSHRCYP3A4MAPTCACNA1B | |
| SCHEMBL2363000 | 0.74 | TSHR (0.42) | TDP1TSHRCYP3A4MAPTCACNA1B | |
| Lactic Acid SCHEMBL27586439 | 0.74 | TP53 (0.46) | TDP1TSHRCYP3A4MAPTCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |