Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Alfuzosin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D known ✓ | P25100 | 3/20 | 0.97 |
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.97 |
| ▸ | ADRA1B known ✓ | P35368 | 3/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.97 |
| ▸ | GLA | P06280 | 5/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.97 |
| ▸ | HPGD | P15428 | 5/20 | 0.97 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.97 |
| ▸ | GAA | P10253 | 4/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.97 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.97 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.97 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.97 |
| ▸ | ACHE | P22303 | 1/20 | 0.97 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.97 |
| ▸ | DRD3 | P35462 | 1/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alfuzosin SCHEMBL1690751 | 1.00 | KDM4E (0.97) | KDM4EGLAALDH1A1HPGDHSD17B10 | |
| Alfuzosin SCHEMBL8108037 | 1.00 | KDM4E (0.97) | KDM4EGLAALDH1A1HPGDHSD17B10 | |
| Alfuzosin SCHEMBL30690015 | 0.99 | KDM4E (0.98) | KDM4EGLAALDH1A1HPGDHSD17B10 | |
| Alfuzosin SCHEMBL4745192 | 0.99 | KDM4E (0.98) | KDM4EGLAALDH1A1HPGDHSD17B10 | |
| Alfuzosin SCHEMBL179910 | 0.99 | KDM4E (0.98) | KDM4EGLAALDH1A1HPGDHSD17B10 | |
| Alfuzosin SCHEMBL4744369 | 0.99 | KDM4E (0.98) | KDM4EGLAALDH1A1HPGDHSD17B10 | |
| Alfuzosin SCHEMBL2851348 | 0.99 | KDM4E (0.98) | KDM4EGLAALDH1A1HPGDHSD17B10 | |
| Alfuzosin SCHEMBL29492949 | 0.99 | KDM4E (0.98) | KDM4EGLAALDH1A1HPGDHSD17B10 | |
| Alfuzosin SCHEMBL1690827 | 0.98 | KDM4E (0.97) | KDM4EGLAALDH1A1HPGDHSD17B10 | |
| Alfuzosin SCHEMBL34477 | 0.98 | KDM4E (1.00) | KDM4EGLAALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0663398-B1 | Dihydrate of N-(4-amino-6,7-dimethoxyquinazol-2-yl)-N-methyl-N'-(tetrahydrofuroyl-2)-propylene diamine hydrochloride (= alfuzosin hydrochloride dihydrate) and a process for the preparation | SANOFI SYNTHELABO (FR) | 2000-03-15 | — | — | EP | disclosed |
| US-5545738-A | USEFUL FOR PRODUCTION OF ANTIHYPERTENSIVE AGENTS AND DYSUREA CURING AGENTS | SYNTHELABO (FR) | 1996-08-13 | — | — | US | disclosed |
| EP-0663398-A1 | Dihydrate of N-(4-amino-6,7-dimethoxyquinazol-2-yl)-N-methyl-N'-(tetrahydrofuroyl-2)-propylene diamine hydrochloride (= alfuzosin hydrochloride dihydrate) and a process for the preparation | SYNTHELABO (FR) | 1995-07-19 | — | — | EP | disclosed |