SCHEMBL8116231

SCHEMBL8116231

CCC(NC(=O)c1c(CN2CC[C@H](O)C2)c(-c2ccccc2)nc2ccccc12)c1ccccc1

nearest known ligand 0.76

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TACR3 P29371 19/20 0.76
TACR2 P21452 9/20 0.76
OPRM1 P35372 6/20 0.75
TRPV4 Q9HBA0 1/20 0.62
CYP1A2 P05177 1/20 0.61
CYP3A4 P08684 1/20 0.61
CYP2D6 P10635 1/20 0.61
CYP2C9 P11712 1/20 0.61
TACR1 P25103 1/20 0.61
CYP2C19 P33261 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5635546 1.00 TACR3 (0.76) TACR3TACR2OPRM1TRPV4CYP1A2
SCHEMBL5636703 0.95 TACR3 (0.81) TACR3TACR2OPRM1TRPV4
SCHEMBL5636697 0.95 TACR3 (0.81) TACR3TACR2OPRM1TRPV4
SCHEMBL6228536 0.85 TACR3 (0.84) TACR3TACR2OPRM1CYP1A2CYP3A4
SCHEMBL6228533 0.85 TACR3 (0.84) TACR3TACR2OPRM1CYP1A2CYP3A4
SCHEMBL5636316 0.85 TACR3 (0.84) TACR3TACR2OPRM1CYP1A2CYP3A4
SCHEMBL5636312 0.85 TACR3 (0.84) TACR3TACR2OPRM1CYP1A2CYP3A4
SCHEMBL5635855 0.85 TACR3 (0.83) TACR3TACR2OPRM1CYP1A2CYP3A4
SCHEMBL8227625 0.85 TACR3 (0.83) TACR3TACR2OPRM1CYP1A2CYP3A4
SCHEMBL5636960 0.85 TACR3 (1.00) TACR3TACR2OPRM1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0983262-A1 QUINOLINE-4-CARBOXAMIDE DERIVATIVES AS NK-2 AND NK-3 RECEPTOR ANTAGONISTS Smithkline Beecham Farmaceutici S.p.A. (IT) 2000-03-08 EP disclosed
WO-1998052942-A1 QUINOLINE-4-CARBOXAMIDE DERIVATIVES AS NK-2 AND NK-3 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM S.P.A. (IT) 1998-11-26 WO disclosed