SCHEMBL8124356

SCHEMBL8124356

N#CCCC1(Cc2ccncc2)c2cccnc2-c2ncccc21

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.40
CYP2C9 P11712 3/20 0.40
CYP1A2 P05177 3/20 0.40
KCNQ2 O43526 1/20 0.40
ALOX15 P16050 1/20 0.40
TSHR P16473 1/20 0.40
MAPK1 P28482 1/20 0.36
CYP2C19 P33261 3/20 0.35
ALDH1A1 P00352 1/20 0.35
CYP2D6 P10635 1/20 0.35
THPO P40225 1/20 0.35
ATM Q13315 1/20 0.33
CYP2C8 P10632 1/20 0.33
CYP46A1 Q9Y6A2 1/20 0.33
CYP11B1 P15538 1/20 0.31
CYP11B2 P19099 1/20 0.31
NPSR1 Q6W5P4 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8118506 0.89 CYP3A4 (0.37) CYP3A4CYP2C9CYP1A2KCNQ2ALOX15
Sibopirdine SCHEMBL120953 0.83 CYP3A4 (0.54) CYP3A4CYP2C9CYP1A2KCNQ2ALOX15
SCHEMBL8111662 0.81 CYP1A2 (0.43) CYP3A4CYP2C9CYP1A2KCNQ2ALOX15
Water SCHEMBL8111654 0.78 CYP3A4 (0.41) CYP3A4CYP2C9CYP1A2KCNQ2ALOX15
Water SCHEMBL120952 0.77 CYP1A2 (0.45) CYP3A4CYP2C9CYP1A2KCNQ2ALOX15
SCHEMBL8119301 0.75 CYP1A2 (0.38) CYP3A4CYP2C9CYP1A2KCNQ2ALOX15
Acetic Acid SCHEMBL8936420 0.74 CYP3A4 (0.40) CYP3A4CYP2C9CYP1A2KCNQ2ALOX15
Hydrochloric Acid SCHEMBL8120335 0.73 KCNQ2 (0.52) CYP3A4CYP2C9CYP1A2KCNQ2ALOX15
SCHEMBL9265681 0.73 KCNQ2 (0.64) CYP3A4CYP2C9CYP1A2KCNQ2ALOX15
SCHEMBL8121667 0.72 CYP3A4 (0.39) CYP3A4CYP2C9CYP1A2KCNQ2ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0623132-B1 DISUBSTITUTED POLYCYCLIC SYSTEMS AS COGNITION ENHANCERS DU PONT PHARM CO (US) 2000-08-09 EP disclosed
US-5532249-A ALZHEIMERS THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1996-07-02 US disclosed
EP-0623132-A1 DISUBSTITUTED POLYCYCLIC SYSTEMS AS COGNITION ENHANCERS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1994-11-09 EP disclosed
WO-1993014092-A1 DISUBSTITUTED POLYCYCLIC SYSTEMS AS COGNITION ENHANCERS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1993-07-22 WO disclosed